Dipeptide diaminobutyroyl benzylamide diacetateCosmetic peptide analogue
Dipeptide diaminobutyroyl benzylamide diacetate is a synthetic cosmetic ingredient often sold under the SYN-AKE name. Its story draws on a venom peptide, but the ingredient is not snake venom.
What is Dipeptide diaminobutyroyl benzylamide diacetate?
Dipeptide diaminobutyroyl benzylamide diacetate is a synthetic cosmetic ingredient associated with the SYN-AKE name. It was designed around a property of a venom-derived molecule; it is not snake venom.
How it works
Its proposed rationale concerns signalling involved in muscle contraction. Whether a topical formulation reaches a relevant target and produces a useful appearance change is a separate question.
Effects studied
Expression-line appearance
The retained clinical lead concerns a cosmetic formulation with multiple ingredients. Any observed appearance change belongs to that tested product; it does not isolate this peptide's contribution. 3
Evidence: Combined-formula clinical lead.
What does the evidence show?
The retained sources include supplier-facing material and a cosmetic research reference. The evidence for a finished formula needs to be separated from the proposed molecular mechanism.
How the ingredient was designed
Researchers can design a small molecule to imitate one property of a much larger natural compound. Here the proposed target is signalling involved in muscle contraction. That explains the name and marketing concept. It does not mean that applying a cream reproduces the effects of venom in the body.
Skin is part of the experiment
For any topical ingredient, activity in a laboratory test must be followed by questions about stability, penetration and exposure at the intended target. A product may improve the appearance of lines without showing that it relaxes facial muscles in the way its advertising suggests.
Which part of a formula made the difference?
Cosmetic studies often test products containing several active ingredients as well as a moisturising base. A change in appearance then belongs to the product as a whole. A before-and-after image cannot isolate this ingredient’s contribution. That requires a comparison designed to test it separately. 3
What “venom effect” tells you about a cream
Treat descriptions such as “venom effect” as a marketing shorthand until a specific outcome and reliable comparison are provided. Tolerability also depends on the finished formula. The ingredient’s synthetic origin neither establishes danger on its own nor provides a guarantee that sensitive skin will tolerate it.
Safety & status
Sensitivity and irritation depend on the finished formula. A proposed muscle-signalling mechanism does not establish that a cosmetic is equivalent to an injected medicine.
Country and product status
This page describes a cosmetic ingredient and its research context. Permitted claims and product availability in Germany and Switzerland need a local check. An ingredient listing does not establish approval to treat a medical condition.
Frequently asked questions
Does SYN-AKE contain snake venom?
The name refers to a synthetic ingredient inspired by a biological property, not the application of snake venom.
Is it a topical equivalent of Botox?
Equivalence is not established. Delivery, mechanism at the target and clinical outcomes require direct evidence.
Sources
This entry was rewritten from our research archive. References below are reading leads unless a completed check is explicitly noted; a full independent evidence and regulatory review is still pending.
- Dipeptide diaminobutyroyl benzylamide diacetate: www.happi.com reference Reference or product information · Retained archive reference; not independently checked for this draft.
- Dipeptide diaminobutyroyl benzylamide diacetate: cosmeticsdesign-europe.com reference Reference or product information · Retained archive reference; not independently checked for this draft.
- Dipeptide diaminobutyroyl benzylamide diacetate: paper 10.1111/ics.70087 Research reference · Retained archive reference; not independently checked for this draft.
Research provenance
This name was discovered in the Superpower peptide index, archived 26 October 2026. Its ratings and reviewer attribution have not been adopted as our own. The archive informed this original editorial draft; independent source review is still pending.