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Enzyme

Diamine Oxidase

Diamine oxidase (DAO) is an enzyme that breaks down histamine, mainly in the gut. Supplements are often made from pig kidney extract.

Gut HealthImmune Support

Short trials leave safety questions open

No adverse effects were recorded in the DAO migraine group over one month. That observation cannot establish long-term safety or safety in pregnancy. 1

Symptoms deserve a broader assessment

The guideline advises considering other causes, including food allergy, celiac disease and carbohydrate malabsorption, rather than relying on DAO testing or extensive food exclusions. 2

For information, not individual medical advice. Ingredient studies do not establish the effectiveness of these products.

Sources

  2. Guideline on management of suspected adverse reactions to ingested histamine DGAKI, GPA, AeDA, SGAI and ÖGAI; Allergologie Select, 2021