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Fatty acid

Eicosapentaenoic Acid

Eicosapentaenoic acid (EPA) is a long-chain omega-3 fatty acid found mainly in fatty fish. The body uses it to make signaling molecules involved in inflammation.

Also listed as EPA, EPA (Eicosapentaenoic Acid)

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What side effects and interactions matter?

Omega-3 supplements can cause digestive discomfort. High doses may increase bleeding problems with anticoagulants, including warfarin; concurrent medicines warrant review. 1

Can a heart supplement affect heart rhythm?

The BfR advises medical discussion before omega-3 supplements in people with cardiovascular disease or risk factors: atrial fibrillation risk increased with higher doses in trials. 2

What does German guidance say about high doses?

The BfR reiterates a precautionary limit of 1.5 g/day combined EPA and DHA from all sources. A prescription regimen is a separate medical decision. 3

What risks are listed for the medicine?

The EMA lists bleeding and atrial fibrillation among common adverse effects of icosapent ethyl. 4

For information, not individual medical advice. Ingredient studies do not establish the effectiveness of these products.

Sources

  1. Omega-3 Fatty Acids: Consumer Fact Sheet NIH Office of Dietary Supplements