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DE
Amino acid derivative

S-Adenosyl Methionine

S-adenosyl-L-methionine, usually shortened to SAMe, is a compound the body makes from the amino acid methionine. It is also manufactured as a supplement.

Also listed as SAME, SAMe, Ademethionine, S-adenosyl-L-methionine

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An injection study is not a tablet study

Some SAMe trials used injections, while others used oral preparations. Liver studies also varied in dose and sometimes combined SAMe with other ingredients, so their results cannot automatically be assigned to a single supplement. The 1,200 mg daily regimen described above is a study dose, not a recommendation. 1 2

A specific European classification

The European Commission’s consultation list, dated October 14, 2026, classifies S-adenosyl-L-methionine disulfate tosylate as not novel in food supplements. This entry concerns the food status of that particular salt form. It is not a clinical finding about effectiveness. 3

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