Inositol
Inositol is a sugar-like substance the body makes and also gets from food. Sometimes called vitamin B8, it is not actually a vitamin.
Also listed as Myoinositol, Cyclohexanehexol, myo-Inositol
Which doses were studied?
Many PCOS trials used 1–4 g of myo-inositol daily, sometimes with folic acid. These are research doses, not a personal dosing recommendation. 1
What side effects are known?
A safety review reported nausea, gas and diarrhea at 12 g daily. The PCOS review also found that most trials did not report adverse events, leaving uncertainty about safety. 1 2
How should treatment decisions be made?
The guideline encourages discussing supplement use with the treating clinician. Inositol for PCOS-related infertility is considered experimental, with uncertain benefits and risks. 3
For information, not individual medical advice. Ingredient studies do not establish the effectiveness of these products.
Sources
- Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines Journal of Clinical Endocrinology & Metabolism, 2024
- Inositol safety: clinical evidences European Review for Medical and Pharmacological Sciences, 2011
- International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023 International PCOS Guideline, 2023