Omega-3 fatty acids
Omega-3 fatty acids are a family of polyunsaturated fats, including ALA from plants and EPA and DHA from fish and algae.
Also listed as Omega3, Omega 3, Omega-3, Total Omega-3 Fatty Acids
What side effects occur?
Common effects are generally mild and include unpleasant taste, heartburn, nausea, gastrointestinal discomfort and diarrhea. High doses can affect platelet activity. NIH advises reviewing use with a clinician when anticoagulants such as warfarin are involved, while noting that most studies did not find a significant change in anticoagulant status. 1
Why is atrial fibrillation a concern?
BfR warns that omega-3 preparations can increase atrial-fibrillation risk in people with heart disease or cardiovascular risk factors, especially at higher doses. Its 2026 guidance reiterates the precaution of no more than 1.5 g EPA plus DHA daily from all sources and recommends medical discussion for these risk groups. This is BfR risk guidance, not an intake target or a claim that ordinary fish meals carry the same risk. 2
Does a safety assessment mean high doses are advisable?
NIH reports earlier EFSA and FDA assessments finding up to about 5 g EPA plus DHA daily generally safe under the assessed conditions. It also notes that subsequent long-term trials found more atrial fibrillation at 4 g daily in high-risk patients. An older safety assessment is therefore not a recommendation to use several grams for general wellness. 1
For information, not individual medical advice. Ingredient studies do not establish the effectiveness of these products.
Sources
- Omega-3 Fatty Acids: Fact Sheet for Health Professionals NIH Office of Dietary Supplements
- Omega-3-Fettsäuren: Wichtig, aber in Maßen Bundesinstitut für Risikobewertung