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Botanical

Sarsaparilla

Sarsaparilla is the root of tropical climbing plants of the genus Smilax, used in traditional herbal medicine and as a flavoring.

Also listed as Sarsaparilla Extract, Sarsaparilla Root, Sarsaparilla Root Extract, Sarsaparilla Glycerite Liquid Extract

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Immune SupportSmallCNo linked study
Cholesterol balanceCardiovascularSmallCNo linked study
Oxidative stressLongevitySmallCNo linked study
Liver healthOrgan FunctionSmallCNo linked study
Gut healthSmallCNo linked study
Skin InflammationHair & SkinSmallCNo linked study
All 8 rated effectsGrouped by health goal, with the publications behind each rating

Which plant is sarsaparilla?

Sarsaparilla names several Smilax species used for their roots. Clinical evidence is limited, and studies do not establish a therapeutic dose. 1

Why people take it

Energy18.4%
Detox13.8%
Immune Support13.8%
Gut Health11.5%
Men's Hormones9.2%
Essential Health6.9%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Is it an established psoriasis treatment?

Clinical evidence supporting this traditional use is lacking. 1

Can a root supplement reproduce the mouse study?

The experiment tested astilbin, not a commercial root supplement; equivalent human effects cannot be inferred. 2

Is there a research-backed dose?

Clinical trials do not provide a therapeutic dosing basis. 1

Sources

  1. Sarsaparilla Drugs.com, 2026