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MSM

MSM, or methylsulfonylmethane, is an organic sulfur compound that occurs in small amounts in some foods. Supplements are made synthetically.

Also listed as Dimethyl Sulfone, Dimethylsulfone, Methylsulfonylmethane

Bone & JointHair & SkinLongevityImmune SupportFitness

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Joint ComfortBone & JointModerateBNo linked study
Anti-aging SkinHair & SkinModerateBNo linked study
Oxidative stressLongevityModerateBNo linked study
Immune SupportModerateBNo linked study
Joint MobilityBone & JointModerateBNo linked study
Muscle RecoveryFitnessSmallBNo linked study
All 9 rated effectsGrouped by health goal, with the publications behind each rating

Could MSM ease an aching knee?

There is a promising signal, but not a settled answer. NCCIH considers the osteoarthritis research too limited for firm conclusions. MSM is sold alone and in mixtures, commonly with glucosamine. 1

Why people take it

Essential Health20%
Bone & Joint19.8%
Immune Support16.2%
Longevity11.2%
Detox7.5%
Fitness5.8%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Is 6 g daily a recommended dose?

It was the amount tested in one 12-week pilot trial, not an established personal dose or a long-term safety limit. 2

Does MSM reliably reduce stiffness?

The pilot trial found no notable stiffness improvement, despite positive pain and function findings. 2

Does a collagen claim on the label prove an MSM benefit?

Not necessarily. German consumer guidance explains that added vitamin C may carry an authorized collagen claim that does not belong to MSM. 3

Sources