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MSM

MSM, or methylsulfonylmethane, is an organic sulfur compound that occurs in small amounts in some foods. Supplements are made synthetically.

Also listed as Dimethyl Sulfone, Dimethylsulfone, Methylsulfonylmethane

What improved in a small trial?

A placebo-controlled trial enrolled 50 adults with knee osteoarthritis. MSM at 3 g twice daily for 12 weeks improved pain and physical-function scores, but stiffness and the overall symptom score did not show notable improvement. The pilot study could not establish long-term benefit or safety. 1

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Bone & Joint2 effects

Joint ComfortBone & JointModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Joint MobilityBone & JointModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Hair & Skin2 effects

Anti-aging SkinHair & SkinModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Skin textureHair & SkinSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Longevity1 effect

Oxidative stressLongevityModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Immune Support2 effects

Immune SupportModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Histamine & Immune BalanceImmune SupportSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Fitness1 effect

Muscle RecoveryFitnessSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Other effects1 effect

InflammationSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Sources