Other
Spermidine
Spermidine is a polyamine, a small molecule found in all living cells and in foods such as wheat germ, soybeans and aged cheese.
Effects by health goal
Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.
Longevity2 effects
No study is linked to this rating.
No study is linked to this rating.
Immune Support1 effect
No study is linked to this rating.
Weight Management1 effect
No study is linked to this rating.
Other effects1 effect
No study is linked to this rating.
All studies
3 publications are linked to Spermidine, newest first.
Keohane et al. — Short-term high-purity spermidine trial2024 · Exploratory randomized, double-blind, placebo-controlled studySchwarz et al. — SmartAge randomized trial2022 · Twelve-month randomized, double-masked, placebo-controlled trialWirth et al. — Spermidine and memory: pilot trial2018 · Three-month randomized, placebo-controlled pilot
Primary studies reviewed by the editorial guide
Wirth et al. — Spermidine and memory: pilot trial
- Year
- 2018
- Design
- Three-month randomized, placebo-controlled pilot
- Participants
- 30 older adults with subjective cognitive decline
- Findings
- Suggested a memory signal; the between-group confidence interval included no effect.
- Limitations
- Pilot-sized sample and imprecise estimate.
Schwarz et al. — SmartAge randomized trial
- Year
- 2022
- Design
- Twelve-month randomized, double-masked, placebo-controlled trial
- Participants
- 100 adults aged 60–90 with subjective cognitive decline
- Findings
- No significant improvement in the primary memory outcome or secondary outcomes.
- Limitations
- One wheat-germ preparation; exploratory signals require confirmation.
Keohane et al. — Short-term high-purity spermidine trial
- Year
- 2024
- Design
- Exploratory randomized, double-blind, placebo-controlled study
- Participants
- 37 healthy men aged 50–70; up to 28 days
- Findings
- Minimal changes in circulating polyamines; no product-related adverse events reported.
- Limitations
- Short duration, selected men and industry involvement; no lifespan outcome.