Pflanzenstoff
Berberin
Berberin ist ein gelbes Pflanzenalkaloid, das unter anderem in Berberitze, Kanadischer Orangenwurzel und Mahonie vorkommt. Untersucht wird es vor allem beim Blutzucker.
Auch bekannt als Berberine Extract 10:1, Dihydroberberine, berberine hcl, berberine hydrochloride
Senkt es den Blutzucker?
Eine Übersicht von 2022 umfasste 37 Studien mit 3.048 Menschen mit Typ-2-Diabetes, fast alle aus China. Untersucht wurde Berberin allein oder zusätzlich zu Diabetesmedikamenten. 1
BlutzuckerWidersprüchlich
Der Langzeitblutzuckerwert HbA1c lag durchschnittlich um 0,63 Prozentpunkte niedriger. Unzureichende Angaben zu Verblindung und Gruppenzuteilung begrenzen die Aussagekraft. 1
Wie überzeugend sind die Ergebnisse zum Abnehmen?
NCCIH bewertet die Daten als nicht eindeutig: Einzelergebnisse unterscheiden sich, viele Studien haben ein hohes Verzerrungsrisiko. 2
Eine natürliche Alternative zur Abnehmspritze?
Die Verbraucherzentrale weist diesen Vergleich zurück; überzeugende Belege für die beworbene GLP-1-Wirkung fehlen. 3
Wirkungen nach Gesundheitsziel
Öffnen Sie eine Wirkung, um die Studien hinter der Bewertung zu sehen. Die Balken zeigen die Größe der Wirkung, der Buchstabe die Qualität der Studienlage.
Gewicht3 Wirkungen
The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-Analysis of Randomized Controlled Trials2023 · Systematic review / meta-analysisGlucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis2022 · Systematic review / meta-analysisThe Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2021 · Systematic review / meta-analysis
Overall and sex-specific effect of berberine on glycaemic and insulin-related traits: a systematic review and meta-analysis of randomized controlled trials2023 · Systematic review / meta-analysisThe Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2021 · Systematic review / meta-analysisThe effect of Berberine on weight loss in order to prevent obesity: A systematic review2020 · Systematic review / meta-analysis
The effect of Berberine on weight loss in order to prevent obesity: A systematic review2020 · Systematic review / meta-analysisThe effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials2020 · Systematic review / meta-analysisThe effect of berberine supplementation on obesity indices: A dose-response meta-analysis and systematic review of randomized controlled trials2020 · Systematic review / meta-analysis
Herz & Kreislauf2 Wirkungen
The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis2022 · Systematic review / meta-analysisEffect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial2021Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials2018 · Systematic review / meta-analysis
The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis2022 · Systematic review / meta-analysisEffect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial2021Berberine for the treatment of hypertension: A systematic review2020 · Systematic review / meta-analysis
Darmgesundheit3 Wirkungen
Organfunktion1 Wirkung
A Comprehensive Insight into the Effect of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD): A Systematic Review2023 · Systematic review / meta-analysisThe Therapeutic Effect of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease: A Meta-Analysis2016 · Systematic review / meta-analysisEfficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease2015
Weitere Wirkungen1 Wirkung
Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models2024 · Animal-model review and meta-analysisThe Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-Analysis of Randomized Controlled Trials2023 · Systematic review / meta-analysisThe effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta-analysis of randomized controlled trials2022 · Systematic review / meta-analysis
Alle Studien
23 Veröffentlichungen sind mit Berberin verknüpft, die neuesten zuerst.
Lei et al. — Berberine and adiposity in adults with obesity and MASLD2026 · Six-month randomized, double-blind, placebo-controlled trialBerberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models2024 · Animal-model review and meta-analysisThe Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-Analysis of Randomized Controlled Trials2023 · Systematic review / meta-analysisBerberine influences multiple diseases by modifying gut microbiota2023A Comprehensive Insight into the Effect of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD): A Systematic Review2023 · Systematic review / meta-analysisOverall and sex-specific effect of berberine on glycaemic and insulin-related traits: a systematic review and meta-analysis of randomized controlled trials2023 · Systematic review / meta-analysisGlucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis2022 · Systematic review / meta-analysisThe effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis2022 · Systematic review / meta-analysisThe effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta-analysis of randomized controlled trials2022 · Systematic review / meta-analysisProtective effect of berberine against LPS-induced injury in the intestine: a review2022 · ReviewThe Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2021 · Systematic review / meta-analysisEffect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial2021Effects of Berberine on the Gastrointestinal Microbiota2021Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine2021The effect of Berberine on weight loss in order to prevent obesity: A systematic review2020 · Systematic review / meta-analysisThe effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials2020 · Systematic review / meta-analysisThe effect of berberine supplementation on obesity indices: A dose-response meta-analysis and systematic review of randomized controlled trials2020 · Systematic review / meta-analysisBerberine for the treatment of hypertension: A systematic review2020 · Systematic review / meta-analysisEfficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials2018 · Systematic review / meta-analysisBerberine and inflammatory bowel disease: A concise review2016 · ReviewThe Therapeutic Effect of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease: A Meta-Analysis2016 · Systematic review / meta-analysisEfficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease2015Yin et al. — Efficacy of berberine in patients with type 2 diabetes mellitus2008 · Three-month pilot; randomized active-comparator arm
Von der Redaktion ausgewertete Originalstudien
Yin et al. — Efficacy of berberine in patients with type 2 diabetes mellitus
- Jahr
- 2008
- Studiendesign
- Dreimonatige Pilotstudie; randomisierter Arm mit aktivem Vergleich
- Teilnehmende
- 36 neu diagnostizierte Erwachsene im randomisierten Arm; separate Zusatztherapie-Kohorte mit 48 Personen
- Ergebnisse
- Blutzuckermarker verbesserten sich während der Behandlung.
- Einschränkungen
- Kleine, kurze Studie; die Zusatztherapie-Kohorte war nicht Teil des randomisierten Vergleichs.
Lei et al. — Berberine and adiposity in adults with obesity and MASLD
- Jahr
- 2026
- Studiendesign
- Sechsmonatige randomisierte, doppelblinde, placebokontrollierte Studie
- Teilnehmende
- 337 Erwachsene mit Adipositas und metabolischer Lebererkrankung, ohne Diabetes
- Ergebnisse
- Keine signifikante Reduktion von viszeralem Fett oder Leberfett gegenüber Placebo.
- Einschränkungen
- Eine klinische Population; sekundäre Biomarker-Ergebnisse waren explorativ.
Quellen
- Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis Frontiers in Pharmacology, 2022 · Studieneintrag
- Berberin zum Abnehmen? Verbraucherzentrale