Caffeine
Caffeine is a natural stimulant of the methylxanthine class found in coffee beans, tea leaves, cocoa and guarana.
Also listed as Coffee extract, Tea extract, 1 3 7-Trimethylxanthine, Caffeine Anhydrous
What it is studied for
The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.
What does caffeine actually improve?
Caffeine most reliably improves alertness, attention and reaction time. Its effects on memory and complex decision-making are less consistent, so feeling more awake is not the same as performing every mental task better. 1
How does it keep you awake?
Caffeine blocks adenosine receptors, interfering with signals involved in sleep pressure. Its stimulating effect can therefore come with a cost to later sleep. 1 2
Key studies
The most recent publications linked to Caffeine's ratings.
Why people take it
SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.
Questions people ask
Is 400 mg a daily goal?
No. It is a safety assessment for healthy adults, not a recommended intake. 3
Can caffeine affect sleep below that amount?
Yes. EFSA notes that even 100 mg near bedtime can affect some adults. 3
Is more better for sport?
Very high doses increase side effects and are not needed for a performance benefit. 4
How can I cut back?
FDA suggests reducing gradually because withdrawal can be unpleasant. 5
Is there one bedtime cutoff for everyone?
No universal cutoff follows from the cited sleep analysis; both dose and timing mattered. 2
Sources
- A review of caffeine’s effects on cognitive, physical and occupational performance Neuroscience & Biobehavioral Reviews, 2016 · Study record
- The effect of caffeine on subsequent sleep: A systematic review and meta-analysis Sleep Medicine Reviews, 2023
- Caffeine EFSA
- International society of sports nutrition position stand: caffeine and exercise performance Journal of the International Society of Sports Nutrition, 2021
