Immunoglobulin G
Immunoglobulin G (IgG) is the most common type of antibody in the blood. Supplements usually take it from bovine colostrum or serum.
Does it help diarrhea-predominant IBS?
A six-week pilot trial randomized 66 adults to 5 or 10 g SBI daily or placebo. Several symptoms improved from baseline in the SBI groups. However, symptom-severity differences versus placebo were not significant, and the trial was not adequately powered for comparisons between groups. 1
Does it repair the gut barrier?
An uncontrolled study of 15 adults tested 5 g twice daily for eight weeks. Bowel function improved, but intestinal permeability and the stool microbiome did not change significantly. Small-intestinal microbial findings suggested a possible mechanism needing further investigation; barrier repair was not demonstrated. 2
What about children?
A small pediatric trial had 15 completers and tested 10 g daily for three weeks. Pain and stool form improved within the SBI group, but the main end-of-treatment stool-frequency reduction was not significant. Larger, longer trials are needed. 3
Effects by health goal
Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.
Gut Health3 effects
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Immune Support4 effects
No study is linked to this rating.
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No study is linked to this rating.