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Peptide

TB-500

TB-500 is a synthetic peptide derived from thymosin beta-4, a small protein found in most human cells.

Immune SupportBone & JointFitness

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Immune responseImmune SupportNo effectFNo linked study
InflammationNo effectFNo linked study
Joint MobilityBone & JointNo effectFNo linked study
Muscle RecoveryFitnessNo effectFNo linked study
Endurance and staminaFitnessNo effectFNo linked study
Injury PreventionFitnessNo effectFNo linked study
Every rating with its studiesGrouped by health goal, with the publications behind each rating

Is TB-500 the same as thymosin beta-4?

FDA’s 2026 evaluation defines TB-500 as an acetylated seven-amino-acid fragment, Ac-LKKTETQ, rather than the full-length thymosin beta-4 molecule. The added acetyl group changes chemical properties, so even studies of the unmodified fragment require caution when applied to TB-500. 1

Questions people ask

Do mouse wound findings prove human recovery benefits?

No. They concern a non-acetylated fragment in aged mice, not a clinical test of TB-500. 1 2

Do thymosin eye-drop trials validate TB-500?

No. The molecule, formulation, route and treated condition differ. 1 3

Is a safe human regimen established?

The FDA safety assessment lacks human exposure information sufficient to establish safety. 4

Is it allowed outside competition?

No. The 2026 WADA prohibition applies at all times. 5

Sources

Further reading

A balance holds a bead chain on one side and a clear lens on the other.GuideTB-500 and wound healing: which evidence applies?A focused review of human findings, preclinical research, product identity and regulatory context.Read the article Illustration of a magnifying glass over an open book.GuideCan peptides get you back to training sooner?After an injury, returning to training raises practical questions: when to try running again, whether a shoulder can take the load and whether another treatment might help. A promise of faster repair can be appealing.Read the article Illustration of a magnifying glass over an open book.GuideCan peptides get you back to training sooner?A closer look at BPC-157, TB-500 and the human evidence behind peptide injury-recovery claims.Read the article Illustration of a magnifying glass over an open book.GuideCan peptides get you back to training faster?What animal studies and limited human data say about BPC-157, TB-500 and recovery from sports injuries, and which questions remain open.Read the article A balance holds a bead chain on one side and a clear lens on the other.GuideTB-500: what the research shows, open questions and how it differs from thymosinTB-500 is marketed for recovery. How research on the fragment can be told apart from studies of full-length thymosin.Read the article