S-Adenosyl Methionineand Mood Support.
Evidence gradeA
ImpactStrong
Confidencehigh
Imported rating. This grade comes from SuppCo and has not been independently reviewed. It describes research, not a product, and it is not medical advice.
The rating
- Direction
- Favourable
- Rated by
- SuppCo
- Observed
- 28 September 2026
Studies behind it
Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence.D. Mischoulon · The American journal of clinical nutrition2002Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysisN. Limveeraprajak · Progress in Neuro-Psychopharmacology and Biological Psychiatry2024S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.Anup Sharma · The Journal of clinical psychiatry2017