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Botanical

Hesperidin

Hesperidin is a flavonoid that occurs naturally in citrus fruit, especially in the peel.

Also listed as hesperitin-7-O-rutinoside, Hesperitin glycoside, glucosyl hesperidin, Vitamin P

LongevityWeight ManagementImmune SupportCardiovascularBone & Joint

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Oxidative stressLongevityModerateA3 studies
InflammationModerateBNo linked study
Blood sugarWeight ManagementModerateBNo linked study
Immune SupportModerateBNo linked study
Blood pressureCardiovascularSmallBNo linked study
Cholesterol balanceCardiovascularSmallBNo linked study
All 10 rated effectsGrouped by health goal, with the publications behind each rating

What is hesperidin?

Hesperidin occurs naturally in citrus fruit, including peel and juice. Glucosyl hesperidin is an enzymatically modified ingredient, so its safety assessment and absorption characteristics should not automatically be assigned to every product called hesperidin. 1

Key studies

The most recent publications linked to Hesperidin's ratings.

A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease2023Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial2017Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models2015

Why people take it

Essential Health20.2%
Immune Support19.8%
Energy12.6%
Cardiovascular10.1%
Bone & Joint9%
Longevity6.7%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Can food supply hesperidin?

Yes. Citrus fruit, including its juice and peel, naturally contains it. 1

Does it reliably lower blood pressure?

The cited cardiovascular meta-analysis found no overall reduction. 2

Does lower CRP mean an inflammatory illness is treated?

No. The review measured biomarkers; it did not establish treatment of inflammatory disease. 3

Sources