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Botanical

Hesperidin

Hesperidin is a flavonoid that occurs naturally in citrus fruit, especially in the peel.

Also listed as hesperitin-7-O-rutinoside, Hesperitin glycoside, glucosyl hesperidin, Vitamin P

LongevityWeight ManagementImmune SupportCardiovascularBone & Joint

What happens to cholesterol?

A meta-analysis of 12 trials with 589 completers found modest reductions in total and LDL cholesterol. HDL and triglycerides did not improve overall, and blood pressure was unchanged. The studies measured risk markers rather than heart attacks or strokes. 1

Cholesterol balanceMixed

Some lipid markers improved; broad cardiovascular protection was not tested. 1

Can it reduce inflammation?

A 2026 review of 16 trials in 845 overweight or obese participants found a modest reduction in CRP, a blood marker of inflammation. Evidence for other markers was less consistent or less certain. The review combined hesperidin with hesperidin-containing citrus interventions, which limits conclusions about one particular capsule. 2

InflammationToo little evidence

A modest CRP signal does not establish treatment of inflammatory disease. 2

What does an antioxidant result mean?

In a six-week trial, 64 people with type 2 diabetes received 500 mg of hesperidin daily or placebo. Several markers of oxidative damage improved. This supports a biological effect in that setting, but does not establish fewer diabetes complications or a benefit for healthy people. 3

Oxidative stressToo little evidence

One short diabetes trial improved oxidative-stress markers. 3

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Weight Management1 effect

Blood sugarWeight ManagementModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Immune Support1 effect

Immune SupportModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cardiovascular2 effects

Blood pressureCardiovascularSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cholesterol balanceCardiovascularSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · high confidenceEvidence record

Bone & Joint1 effect

Bone densityBone & JointSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cognition2 effects

MemoryCognitionSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Focus And AttentionCognitionSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Hair & Skin1 effect

Skin InflammationHair & SkinSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Other effects1 effect

InflammationModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

All studies

3 publications are linked to Hesperidin, newest first.

A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease2023Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial2017Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models2015

Sources