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Hyaluronic Acid

Hyaluronic acid, also called hyaluronan, is a compound the body makes itself and is present in skin and joint fluid.

Also listed as Hyaluronan, Hyaluronate (as sodium or potassium salt)

Hair & SkinBone & JointLongevity

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Skin HydrationHair & SkinModerateA3 studies
Skin textureHair & SkinModerateB2 studies
Joint MobilityBone & JointSmallB2 studies
Cellular health & agingLongevitySmallB2 studies
Skin InflammationHair & SkinSmallC2 studies
Every rating with its studiesGrouped by health goal, with the publications behind each rating

Can a capsule help dry skin?

Oral hyaluronic acid has promising trial results for skin hydration. A seven-trial analysis found improvements in hydration, elasticity and wrinkle depth, but studies were small and varied. 1

What is hyaluronic acid?

Hyaluronan is another name for hyaluronic acid, a compound made by the body and present in skin and joint fluid. Its normal role in these tissues does not by itself establish what swallowing it achieves. 2

Key studies

The most recent publications linked to Hyaluronic Acid's ratings.

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation2021Oral administration of hyaluronic acid to improve skin conditions via a randomized double‐blind clinical testOral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled StudyIngestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical StudyOral hyaluronan relieves knee pain: a review
All 6 studiesEvery publication linked to Hyaluronic Acid

Why people take it

Bone & Joint21.1%
Essential Health19.3%
Longevity16%
Hair & Skin14.7%
Immune Support11.1%
Fitness4.1%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

How quickly were effects measured?

In the 2021 trial, several differences emerged after 8–12 weeks, not immediately. 3

Does it work like an injection?

The oral studies do not establish equivalence to joint injections; these are different interventions. 2

Is more necessarily better?

The newer trial compared only 60 and 120 mg daily with placebo; it does not establish benefits from progressively higher doses. 4

Does it improve every sign of skin aging?

No. The meta-analysis found positive results for some measures and no significant benefit for others. 1

Sources

Further reading

Illustration for Hyaluronic Acid.GuideOral hyaluronic acid: what the research shows for skin and jointsOral hyaluronic acid for skin and joints: study results, amounts tested and the limits of how far the findings apply.Read the article