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Enzyme

Nattokinase

Nattokinase is an enzyme from natto, a Japanese fermented-soybean food.

Also listed as Natto extract, subtilisin NAT, Orokinase, NSK-SD

CardiovascularEssential HealthWeight Management

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Blood pressureCardiovascularModerateA3 studies
Cholesterol balanceCardiovascularModerateBNo linked study
Essential HealthModerateBNo linked study
InflammationSmallCNo linked study
Blood sugarWeight ManagementSmallCNo linked study
Every rating with its studiesGrouped by health goal, with the publications behind each rating

What is nattokinase?

Nattokinase is an enzyme from natto, a Japanese fermented-soybean food. 1

Does breaking down fibrin prove protection?

EFSA describes fibrin-degrading activity in laboratory tests, but found the submitted evidence insufficient to establish absorption of active enzyme or functional metabolites. Laboratory activity alone cannot establish protection from stroke. 2

Key studies

The most recent publications linked to Nattokinase's ratings.

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2023Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial2016Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial2008

Why people take it

Cardiovascular23%
Immune Support18.5%
Essential Health16.5%
Longevity16.4%
Energy5.2%
Gut Health4.1%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Has nattokinase been shown to slow artery-wall thickening?

The three-year trial found no significant benefit at 2,000 fibrinolytic units daily. 3

Can I replace an anticoagulant with nattokinase?

German guidance warns against replacing prescribed anticoagulation without medical consultation. 1

Does enzyme activity prove stroke prevention?

No. Laboratory fibrin breakdown does not establish absorption or prevention of clinical events. 2

Sources