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Enzyme

Nattokinase

Nattokinase is an enzyme from natto, a Japanese fermented-soybean food.

Also listed as Natto extract, subtilisin NAT, Orokinase, NSK-SD

CardiovascularEssential HealthWeight Management

Can it lower blood pressure?

A 2023 meta-analysis pooled three blood-pressure trials with 223 participants. Average reductions versus placebo were approximately 3.5 mmHg systolic and 2.3 mmHg diastolic. This modest signal does not establish prevention of heart attacks or strokes. 1

Blood pressureMixed

Short-trial pooled findings were positive, while the longer trial found no blood-pressure effect. 1 2

What happened over three years?

A trial randomized 265 adults without clinical cardiovascular disease to 2,000 fibrinolytic units daily or placebo. Over a median three years, artery-wall thickening, arterial stiffness, blood pressure and laboratory outcomes did not significantly differ. The result concerns this dose and relatively low-risk population. 2

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Essential Health1 effect

Essential HealthModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Weight Management1 effect

Blood sugarWeight ManagementSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Other effects1 effect

InflammationSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

All studies

3 publications are linked to Nattokinase, newest first.

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2023Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial2016Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial2008

Sources