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Enzyme

Papain

Papain is a protein-splitting enzyme obtained from the milky latex of unripe papaya fruit.

Immune SupportGut HealthHair & Skin

Does it relieve bloating?

A placebo-controlled trial reported improvements in bloating and constipation with Caricol, a papaya preparation. It did not test isolated papain, so it cannot establish that a papain capsule produces the same result. 1

Bloating & gas reliefToo little evidence

Evidence for a papaya preparation cannot identify papain’s individual effect. 1

What about inflammation claims?

Germany’s Verbraucherzentrale concludes that reliable human evidence is insufficient for the anti-inflammatory effects claimed for papain. Its protein-splitting action alone does not establish a clinical benefit. 2

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Immune Support1 effect

Immune SupportSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Gut Health3 effects

Microbiome healthGut HealthSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Bloating & gas reliefGut HealthSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Gut healthSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Hair & Skin1 effect

Skin InflammationHair & SkinSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Other effects1 effect

InflammationSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Sources