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Enzyme

Cellulase

Cellulase is a group of enzymes that break down cellulose, the main fiber in plant cell walls. Humans do not make it; supplement cellulase usually comes from fungi.

Gut Health

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Microbiome healthGut HealthSmallCNo linked study
Bloating & gas reliefGut HealthSmallCNo linked study
Gut healthSmallCNo linked study
Digestive sensitivityGut HealthNo effectFNo linked study
ConstipationNo effectFNo linked study
DiarrheaNo effectFNo linked study
Every rating with its studiesGrouped by health goal, with the publications behind each rating

What does cellulase do?

Cellulase cuts bonds in cellulose and related carbohydrates, producing shorter chains. That biochemical action is distinct from demonstrating symptom relief after a meal. 1 2

Why people take it

Immune Support19.2%
Essential Health19.2%
Gut Health18.6%
Detox13%
Energy12.5%
Bone & Joint3%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Does cellulase digest cellulose?

Yes. It breaks certain bonds in cellulose into shorter chains. 1

Does a positive enzyme-blend trial prove cellulase works?

No. Combination trials cannot identify which ingredient produced a benefit without testing the components separately. 2

Can it treat diarrhea after meals?

Mixed-enzyme research includes meal-related diarrhea, but the review did not establish a cellulase-specific effect. 2

Does EFSA’s opinion mean every supplement is safe?

No. The opinion covers a defined enzyme preparation and specified food-manufacturing uses. 1

Sources