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Botanical

Grape Seed Extract

Grape seed extract comes from the seeds of wine grapes and contains proanthocyanidins. It has been studied for blood pressure and cholesterol, among other uses.

Also listed as GSE, OPC-3, Oligomeric Procyanidins, Procyanidin

LongevityCardiovascularImmune SupportHair & SkinCognition

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Oxidative stressLongevityModerateA3 studies
Blood pressureCardiovascularModerateA3 studies
Cellular health & agingLongevityModerateBNo linked study
Immune SupportModerateBNo linked study
InflammationModerateBNo linked study
Skin textureHair & SkinSmallBNo linked study
All 9 rated effectsGrouped by health goal, with the publications behind each rating

What is grape seed extract?

Grape seed extract comes from the seeds of wine grapes and contains proanthocyanidins. Researchers have studied it for blood pressure and cholesterol, among other uses. 1

Why study an antioxidant extract?

One proposed benefit is limiting oxidation of fats, a process examined through blood markers such as oxidized LDL. Human trials have found changes in some of these markers; that is a narrower finding than preventing illness or slowing aging. 2

Key studies

The most recent publications linked to Grape Seed Extract's ratings.

Grape seed extract supplementation in non-alcoholic fatty liver disease.2024Grape Seed Components as Protectors of Inflammation, DNA Damage, and Cancer2023The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials2021Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers2021The Effect of Grape (Vitis vinifera) Seed Extract Supplementation on Flow-Mediated Dilation, Blood Pressure, and Heart Rate: A Systematic Review and Meta-Analysis of Controlled Trials with Duration- and Dose-Response Analysis.2021
All 6 studiesEvery publication linked to Grape Seed Extract

Why people take it

Immune Support17.7%
Essential Health16.1%
Energy12.1%
Longevity9.7%
Cardiovascular8.8%
Detox7.3%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Does it lower both blood-pressure numbers?

The 19-trial review found a modest reduction in diastolic pressure, but no statistically clear reduction in systolic pressure. 3

Do better antioxidant markers prove an anti-aging effect?

No. The cited review measured blood markers, not lifespan or healthy years gained. 2

Can I use it while breastfeeding?

There is little information about safety during breastfeeding, according to NCCIH. 1

Sources