Skip to content
DE
Botanical

Grape Seed Extract

Grape seed extract comes from the seeds of wine grapes and contains proanthocyanidins. It has been studied for blood pressure and cholesterol, among other uses.

Also listed as GSE, OPC-3, Oligomeric Procyanidins, Procyanidin

LongevityCardiovascularImmune SupportHair & SkinCognition

Does it lower blood pressure?

A review of 19 controlled trials in adults found an average 2.2 mmHg reduction in diastolic pressure, the lower number in a blood-pressure reading. Systolic pressure and a measure of blood-vessel dilation did not improve significantly. Results varied substantially between studies. 1

Blood pressureMixed

The lower blood-pressure number improved modestly, while the upper number did not show a clear benefit across the trials. 1

What changed in antioxidant studies?

A 2021 analysis found lower malondialdehyde and oxidized LDL, both markers of fat oxidation. High-sensitivity CRP also fell, but standard CRP and white-blood-cell counts did not change significantly. These are laboratory outcomes rather than evidence of fewer diseases. 2

Oxidative stressToo little evidence

Some oxidation markers improved; the clinical importance of those changes remains uncertain. 2

InflammationMixed

Inflammation results differed between markers, with a benefit for high-sensitivity CRP but not all measures. 2

Other questions

This page does not assess memory, brain fog, skin texture or infection prevention.

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Immune Support1 effect

Immune SupportModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Hair & Skin1 effect

Skin textureHair & SkinSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cognition2 effects

MemoryCognitionSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Brain FogCognitionSmallCNo linked study

No study is linked to this rating.

Rated by SuppCo · low confidenceEvidence record

Other effects1 effect

InflammationModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

All studies

6 publications are linked to Grape Seed Extract, newest first.

Grape seed extract supplementation in non-alcoholic fatty liver disease.2024Grape Seed Components as Protectors of Inflammation, DNA Damage, and Cancer2023The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials2021Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers2021The Effect of Grape (Vitis vinifera) Seed Extract Supplementation on Flow-Mediated Dilation, Blood Pressure, and Heart Rate: A Systematic Review and Meta-Analysis of Controlled Trials with Duration- and Dose-Response Analysis.2021The impact of grape seed extract treatment on blood pressure changes2016

Sources