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Amino acid

L-Glutamine

Glutamine is an amino acid the body produces and also obtains from food. It is especially abundant in muscle and blood.

Also listed as Glutamine

Gut HealthImmune SupportFitness

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

Gut healthStrongA3 studies
Gut IntegrityGut HealthModerateA3 studies
Immune SupportModerateBNo linked study
Muscle RecoveryFitnessSmallCNo linked study
Digestive sensitivityGut HealthSmallCNo linked study
Every rating with its studiesGrouped by health goal, with the publications behind each rating

What is glutamine?

Glutamine is an amino acid the body produces and obtains from food. It is especially abundant in muscle and blood. 1

Key studies

The most recent publications linked to L-Glutamine's ratings.

A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults2024The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review2019Glutamine and the preservation of gut integrity1993

Why people take it

Energy18.3%
Essential Health17.6%
Fitness16.6%
Immune Support15.3%
Gut Health9.7%
Cognition4.9%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Does glutamine treat every kind of IBS?

The positive trial concerned post-infectious diarrhea-predominant IBS with increased permeability. 2

Does a null pooled result mean nobody benefits?

No. The review included positive subgroup findings, but they do not establish a dependable treatment rule. 3

Can intensive-care results be applied to healthy users?

The harmful trial involved multiorgan failure and combined intravenous and enteral treatment. Its population and route matter. 4

Sources