Lithium Orotate
Lithium orotate is a salt of the element lithium and orotic acid. It is sold as a low-dose supplement, unlike lithium carbonate, which is a prescription drug.
What it is studied for
The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.
How is it different from prescription lithium?
Lithium orotate is a lithium salt. A 2021 review found major gaps in comparisons with prescription lithium carbonate. 1
Why people take it
SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.
Questions people ask
Is lithium orotate a proven gentler form?
No reliable human comparison in the cited review established that advantage. Animal findings included both higher brain levels and kidney-safety concerns. 1
Does a negative rat toxicity study prove safety for years?
No. The repeated-dose study lasted 28 days in rats, not years in people. 2
Does being available online mean it is authorized in the EU?
No. BZfE states that lithium is not authorized for use in supplements, regardless of its chemical form. 3
Sources
- Lithium orotate: A superior option for lithium therapy? Brain and Behavior, 2021
- A toxicological evaluation of lithium orotate Regulatory Toxicology and Pharmacology, 2021
- Lithium als Nahrungsergänzungsmittel Bundeszentrum für Ernährung