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Botanical

Grape

Grapes are the fruit of the grapevine, Vitis vinifera. Supplements use extracts of the fruit, skin, seeds or leaves.

Also listed as Grape Extract, Grape Fruit, Grape Fruit Extract, Grape fruit skin

LongevityImmune SupportCognitionCardiovascular

Can grape products improve cholesterol?

A 2020 meta-analysis found LDL cholesterol about 6.3 mg/dL lower than with placebo. Results varied greatly across studies and preparations, so this average cannot be turned into a reliable effect for a daily handful of grapes. 1

Cholesterol balanceMixed

The pooled LDL result favored grape products, but large differences between trials limit confidence in a predictable benefit from any one form. 1

What does the antioxidant research show?

A 2021 review of 24 randomized trials found a small reduction in CRP, an inflammation marker. Several other measures, including malondialdehyde and total antioxidant capacity, did not improve significantly. Changes in a few markers should not be read as evidence of a longer life. 2

Oxidative stressMixed

The reviewed grape products did not consistently improve the measured oxidation and antioxidant markers. 2

Questions beyond this review

This profile does not assess memory, immune protection or a specific blood-pressure regimen.

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Immune Support1 effect

Immune SupportModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cognition1 effect

MemoryCognitionSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

Cardiovascular2 effects

Cholesterol balanceCardiovascularSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · high confidenceEvidence record

Blood pressureCardiovascularSmallBNo linked study

No study is linked to this rating.

Rated by SuppCo · high confidenceEvidence record

All studies

3 publications are linked to Grape, newest first.

Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials2021Grape polyphenols supplementation for exercise-induced oxidative stress2021Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress.2005

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