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Bacteria

Lactobacillus plantarum

Lactobacillus plantarum, now named Lactiplantibacillus plantarum, is a lactic acid bacterium common in fermented plant foods such as sauerkraut, kimchi and sourdough.

Gut HealthImmune Support

What it is studied for

The strongest rated effects first. Bars show the size of the effect, the letter grades the evidence, and each rating lists the studies behind it.

DiarrheaStrongA3 studies
InflammationModerateA3 studies
Gut healthModerateA3 studies
Immune SupportModerateA3 studies
Microbiome healthGut HealthModerateA3 studies
ConstipationModerateBNo linked study
All 8 rated effectsGrouped by health goal, with the publications behind each rating

Why do the letters and numbers matter?

Lactobacillus plantarum, now also called Lactiplantibacillus plantarum, is a bacterial species studied in probiotic products. A strain is a particular member of that species, identified by a code such as 299v or CCFM1143. Evidence for one strain does not automatically apply to another. Product amounts are expressed as CFU, colony-forming units, which estimate viable organisms. 1 2

What might these bacteria do in the gut?

Probiotics can interact with the intestinal barrier, immune system and other microbes. In a human CCFM1143 trial, researchers measured changes in stool bacteria, short-chain fatty acids and inflammatory signals alongside bowel symptoms. Those observations suggest possible pathways; they do not establish that a particular microbiome change caused the improvement. 2 3

Key studies

The most recent publications linked to Lactobacillus plantarum's ratings.

Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism2023Effect of Oral Intake of Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) on Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study2022Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial2022Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Regulation and Gut Microbiota Modulation: A Double-Blind, Randomized, Placebo-Controlled Study2021Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation2021
All 14 studiesEvery publication linked to Lactobacillus plantarum

Why people take it

Gut Health25.4%
Immune Support25.1%
Essential Health22.4%
Detox9.2%
Energy6.1%
Women's Hormones2.8%

SuppCo community snapshot, 2026-09-28. Reasons for use are not evidence that it works.

Questions people ask

Are Lactobacillus and Lactiplantibacillus plantarum different?

The newer genus name is Lactiplantibacillus. For matching a study, the strain code remains essential. 1

Does 299v help bloating?

Results depend on the measure: the 2026 meta-analysis found more people reporting improvement in flatulence, but no significant reduction in bloating/flatulence severity. 1

Is it proven for constipation?

The 299v meta-analysis did not find a significant improvement in constipation resolution. That result concerns this strain and outcome. 1

Are more billions better?

Not necessarily. Strain, tested purpose and viable count at use matter more than a high number by itself. 2

Does it need refrigeration?

Storage depends on the product. Some require refrigeration and others do not; the label should give the conditions needed through the use-by date. 4

Can it reset my microbiome?

The CCFM1143 trial observed changes in microbes and metabolites, but did not establish a universal healthy microbiome target or a lasting reset. 3

Sources