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Enzyme

Coenzyme Q10

Coenzyme Q10 is a fat-soluble, vitamin-like compound the body makes itself. It sits in cell membranes and takes part in energy production in the mitochondria.

Also listed as coq10, co q10, ubiquinone, ubiquinol

CardiovascularLongevityFitnessImmune SupportEnergy

Can it ease fatigue?

A 2022 review pooled 13 trials with 1,126 participants followed for 4–24 weeks. Fatigue improved overall, but results varied considerably across conditions, doses, and measurement scales. The healthy-participant subgroup did not show a statistically clear benefit. The review therefore offers a useful signal for fatigue research, not a dependable promise of more everyday energy. 1

Physical EnergyMixed

The pooled benefit was clearer among participants with illness than in the smaller healthy subgroup. 1

Why heart failure is a separate conversation

Cochrane found that CoQ10 probably reduced deaths and heart-failure admissions, with evidence no better than moderate quality. A 2024 review of 33 studies also reported fewer deaths and admissions when CoQ10 was added to treatment. These are findings in diagnosed heart failure, not evidence that a supplement prevents heart disease in healthy people. 2 3

What about statin muscle pain?

NCCIH concludes that the overall evidence does not support CoQ10 for muscle pain caused by statins. Its summary also finds little evidence of a meaningful blood-pressure effect. A cellular mechanism alone cannot settle either clinical question. 4

Blood pressureToo little evidence

The limited evidence summarized by NCCIH suggests little meaningful effect. 4

Effects by health goal

Open an effect to see the studies behind its rating. Bars show the size of the effect; the letter grades the evidence.

Hair & Skin1 effect

Skin textureHair & SkinModerateBNo linked study

No study is linked to this rating.

Rated by SuppCo · medium confidenceEvidence record

All studies

22 publications are linked to Coenzyme Q10, newest first.

The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and oxidative stress: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.2024Recovery response of coenzyme Q10 to exercise-related physiological muscle damage, inflammation and oxidative stress: A systematic review2024Coenzyme Q10 and Dementia: A Systematic Review2023Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population2022Coenzyme Q10 Supplementation and Its Impact on Exercise and Sport Performance in Humans: A Recovery or a Performance-Enhancing Molecule?2022Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.2022Coenzyme Q10 and Immune Function: An Overview2021Coenzyme Q10, Ageing and the Nervous System: An Overview2021The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials2020Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases2020Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.2019The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials2018Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis2017Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial.2015Antifatigue effects of coenzyme Q10 during physical fatigue.2008Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials2007Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes2002Coenzyme Q10 in essential hypertension.1994Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the ProblemEffectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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